MolNFT v1 · #85097 · protein
Human myelin P2 protein, K65Q mutant
4A1Y: “Human myelin P2 protein, K65Q mutant”. X-ray diffraction, 2 ligands (PLM, CL), 6 pockets (best druggability 0.83). MolNFT v1 #85097 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 4A1Y
- Type
- protein
- Length
- 532 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myelin P2 protein
- UniProt
- P02689
- Ligands
- PLM, CL
- Pockets
- 6 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 15% helix, 60% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Myelin P2 protein | protein | 133 | 15% helix, 60% strand | P02689 |
Ligands and binding sites
- PLM · Palmitic acid · ligand · 4 copies · chains A, B, C, D
- CL · Chloride ion · ion · 3 copies · chains A, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 394 | 0.83 | 0.91 | 39 | PLM |
| 2 | 363 | 0.82 | 0.91 | 37 | PLM |
| 3 | 366 | 0.82 | 0.91 | 37 | PLM |
| 4 | 387 | 0.81 | 0.90 | 42 | CL, PLM |
| 5 | 1006 | 0.78 | 0.79 | 101 | empty |
Interfaces
5 interfaces between chains.
- A–C · 545 Ų buried · 14 hydrogen bonds · protein-protein
- A–D · 194 Ų buried · 2 hydrogen bonds · protein-protein
- B–C · 170 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 170 Ų buried · 4 hydrogen bonds · protein-protein
- B–D · 170 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02689
- Elsewhere: RCSB PDB 4A1Y · PDBe 4A1Y · UniProt P02689
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.