MolNFT v1 · #85091 · protein

Crystallographic structure of the PINS:INSC complex

4A1S · Partner of inscuteable: “Crystallographic structure of the PINS:INSC complex”. X-ray diffraction, 7 pockets (best druggability 0.49). MolNFT v1 #85091 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4A1S
Type: protein
Length: 746 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Partner of inscuteable; RE60102P
UniProt: Q9NH88, Q5BIH3
Pockets: 7 · best druggability 0.49

Structure

x-ray diffraction · 4 distinct chains · 81% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Partner of inscuteable	protein	346	86% helix, 0% strand	Q9NH88
B	Partner of inscuteable	protein	342	85% helix, 0% strand	Q9NH88
C	RE60102P	protein	30	30% helix, 0% strand	Q5BIH3
E	RE60102P	protein	28	32% helix, 0% strand	Q5BIH3

Pockets

7 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	182	0.49	0.77	30	empty
2	94	0.48	0.81	15	empty
3	154	0.47	0.77	25	empty
4	90	0.45	0.80	21	empty
5	70	0.41	0.80	17	empty

Interfaces

2 interfaces between chains.

A–C · 1997 Å² buried · 35 hydrogen bonds · protein-protein
B–E · 1962 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

4A1S · Crystallographic structure of the Pins:Insc complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NH88
Every structure of UniProt Q5BIH3
Elsewhere: RCSB PDB 4A1S · PDBe 4A1S · UniProt Q9NH88 · UniProt Q5BIH3

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