MolNFT v1 · #85078 · protein

Human KIF7, a kinesin involved in hedgehog signalling

4A14 · Kinesin-like protein KIF7: “Human KIF7, a kinesin involved in hedgehog signalling”. X-ray diffraction, 2 ligands (ADP, MG), 2 pockets (best druggability 0.38). MolNFT v1 #85078 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 4A14
Type: protein
Length: 296 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kinesin-like protein KIF7
UniProt: Q2M1P5
Ligands: ADP, MG
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 1 distinct chain · 35% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Kinesin-like protein KIF7	protein	296	35% helix, 28% strand	Q2M1P5

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	102	0.38	0.75	19	empty
2	83	0.36	0.76	19	empty

Compared structures

4A14 · Human KIF7, a kinesin involved in hedgehog signalling · the same entry in another collection · chain A against A, TM-score 1.00
Q2M1P5 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF7 (Q2M1P5) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q2M1P5
Elsewhere: RCSB PDB 4A14 · PDBe 4A14 · UniProt Q2M1P5

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