MolNFT v1 · #85056 · protein
Crystal structure of survivin bound to the N-terminal tail of HSGO1
4A0I · Baculoviral iap repeat-containing protein 5: “Crystal structure of survivin bound to the N-terminal tail of HSGO1”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.58). MolNFT v1 #85056 on GenesisL1: 3D structure…
- PDB
- 4A0I
- Type
- protein
- Length
- 281 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Baculoviral iap repeat-containing protein 5; Shugoshin-like 1
- UniProt
- O15392, Q5FBB7
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 3 distinct chains · 52% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Baculoviral iap repeat-containing protein 5 | protein | 136 | 55% helix, 7% strand | O15392 |
| B | Baculoviral iap repeat-containing protein 5 | protein | 137 | 51% helix, 7% strand | O15392 |
| C, D | Shugoshin-like 1 | protein | 4 | 0% helix, 50% strand | Q5FBB7 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 127 | 0.58 | 0.84 | 25 | empty |
| 2 | 122 | 0.51 | 0.80 | 19 | empty |
| 3 | 108 | 0.48 | 0.80 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–B · 482 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 392 Ų buried · 9 hydrogen bonds · protein-protein
- B–D · 360 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4A0I · Crystal structure of Survivin bound to the N-terminal tail of hSgo1 · the same entry in another collection · chain A against A, TM-score 1.00
- O15392 · AlphaFold monomer V2.0 prediction for baculoviral iap repeat- containing protein 5… · a predicted model of the same protein · chain B against A, TM-score 0.98
- Q5FBB7 · AlphaFold monomer V2.0 prediction for shugoshin 1 (Q5FBB7) · a predicted model of the same protein · chain C against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15392
- Every structure of UniProt Q5FBB7
- Elsewhere: RCSB PDB 4A0I · PDBe 4A0I · UniProt O15392 · UniProt Q5FBB7
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