MolNFT v1 · #85021 · RNA
Crystal structure and improved antisense properties of 2'-O-(2- methoxyethyl)-RNA
471D · RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)…: “Crystal structure and improved antisense properties of 2'-O-(2- methoxyethyl)-RNA”. X-ray diffraction, 1 ligand (MG), 1 pocket (best druggability 0.53). MolNFT v1 #85021…
- PDB
- 471D
- Type
- RNA
- Length
- 24 nucleotides
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)…
- Ligands
- MG
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36) P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3') | rna | 12 | — | — |
Ligands and binding sites
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 336 | 0.53 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 768 Ų buried · 45 hydrogen bonds · nucleic-nucleic
Modifications
Observed in the structure: 24 modified (nucleotide modification).
Compared structures
- 471D · Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 471D · PDBe 471D
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