MolNFT v1 · #84942 · protein
Crystal structure of staphylococcus aureus elongation factor G with mutations M16I and F88L
3ZZU: “Crystal structure of staphylococcus aureus elongation factor G with mutations M16I and F88L”. X-ray diffraction, 20 pockets (best druggability 0.75). MolNFT v1 #84942 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3ZZU
- Type
- protein
- Length
- 1,296 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Elongation factor G
- UniProt
- P68790
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Elongation factor G | protein | 648 | 30% helix, 31% strand | P68790 |
Pockets
20 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1015 | 0.75 | 0.78 | 91 | empty |
| 2 | 849 | 0.75 | 0.79 | 99 | empty |
| 3 | 135 | 0.55 | 0.82 | 24 | empty |
| 4 | 125 | 0.55 | 0.82 | 19 | empty |
| 5 | 177 | 0.50 | 0.77 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 458 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3ZZU · Crystal structure of Staphylococcus aureus elongation factor G with mutations M16I and… · the same entry in another collection · chain A against A, TM-score 1.00
- P68790 · AlphaFold monomer V2.0 prediction for elongation factor G (P68790) · a predicted model of the same protein · chain A against A, TM-score 0.75
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68790
- Elsewhere: RCSB PDB 3ZZU · PDBe 3ZZU · UniProt P68790
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