MolNFT v1 · #84916 · protein

Crystal structure of 3C protease mutant (T68A and N126Y) of coxsackievirus B3

3ZZ4 · 3C proteinase: “Crystal structure of 3C protease mutant (T68A and N126Y) of coxsackievirus B3”. X-ray diffraction, 1 pocket (best druggability 0.58). MolNFT v1 #84916 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3ZZ4
Type: protein
Length: 362 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 3C proteinase
EC: 3.4.22.28
UniProt: Q90092
Pockets: 1 · best druggability 0.58

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 59% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	3C proteinase (EC 3.4.22.28)	protein	181	13% helix, 59% strand	Q90092

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	339	0.58	0.76	41	empty

Interfaces

1 interface between chains.

A–B · 325 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

3ZZ4 · Crystal structure of 3C protease mutant (T68A and N126Y) of coxsackievirus B3 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q90092
Elsewhere: RCSB PDB 3ZZ4 · PDBe 3ZZ4 · UniProt Q90092

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