MolNFT v1 · #84843 · protein
Crystal structure of plasmodium falciparum AMA1 in complex with a 39AA PFRON2 peptide
3ZWZ · Apical membrane antigen 1, AMA1: “Crystal structure of plasmodium falciparum AMA1 in complex with a 39AA PFRON2 peptide”. X-ray diffraction, 1 pocket (best druggability 0.61). MolNFT v1 #84843 on GenesisL1: 3D structure, binding…
- PDB
- 3ZWZ
- Type
- protein
- Length
- 333 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apical membrane antigen 1, AMA1; Rhoptry neck protein 2
- UniProt
- Q7KQK5, Q8IKV6
- Pockets
- 1 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 15% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apical membrane antigen 1, AMA1 | protein | 297 | 15% helix, 31% strand | Q7KQK5 |
| B | Rhoptry neck protein 2 | protein | 36 | 14% helix, 25% strand | Q8IKV6 |
Ligands and binding sites
- GOL · Glycerol · additive · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 144 | 0.61 | 0.84 | 24 | GOL |
Interfaces
1 interface between chains.
- A–B · 1653 Ų buried · 26 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 3ZWZ · Crystal structure of Plasmodium falciparum AMA1 in complex with a 39aa PfRON2 peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7KQK5
- Every structure of UniProt Q8IKV6
- Elsewhere: RCSB PDB 3ZWZ · PDBe 3ZWZ · UniProt Q7KQK5 · UniProt Q8IKV6
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