MolNFT v1 · #84750 · protein
Crystal structure of a designed selected ankyrin repeat protein in complex with the MAP kinase ERK2
3ZU7 · Mitogen-activated protein kinase 1: “Crystal structure of a designed selected ankyrin repeat protein in complex with the MAP kinase ERK2”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #84750 on GenesisL1: 3D…
- PDB
- 3ZU7
- Type
- protein
- Length
- 498 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 1; Designed ankyrin repeat protein
- EC
- 2.7.11.24
- UniProt
- P63086
- Pockets
- 3 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 1 (EC 2.7.11.24) | protein | 344 | 38% helix, 14% strand | P63086 |
| B | Designed ankyrin repeat protein | protein | 154 | 55% helix, 0% strand | — |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 768 | 0.74 | 0.79 | 93 | empty |
| 2 | 334 | 0.61 | 0.78 | 35 | empty |
| 3 | 90 | 0.56 | 0.86 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 953 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
- 3ZU7 · Crystal structure of a designed selected Ankyrin Repeat protein in complex with the MAP… · the same entry in another collection · chain A against A, TM-score 1.00
- P63086 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 1 (P63086) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63086
- Elsewhere: RCSB PDB 3ZU7 · PDBe 3ZU7 · UniProt P63086
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