MolNFT v1 · #84461 · protein

Structure of group a streptococcal enolase

3ZLH: “Structure of group a streptococcal enolase”. X-ray diffraction, 17 pockets (best druggability 0.83). MolNFT v1 #84461 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3ZLH
Type: protein
Length: 1,719 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Enolase
EC: 4.2.1.11
UniProt: Q5XD01
Pockets: 17 · best druggability 0.83

Structure

x-ray diffraction · 4 distinct chains · 41% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Enolase (EC 4.2.1.11)	protein	430	41% helix, 18% strand	Q5XD01
B	Enolase (EC 4.2.1.11)	protein	432	41% helix, 18% strand	Q5XD01
C	Enolase (EC 4.2.1.11)	protein	425	41% helix, 17% strand	Q5XD01
D	Enolase (EC 4.2.1.11)	protein	432	41% helix, 18% strand	Q5XD01

Pockets

17 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	170	0.83	0.98	24	empty
2	181	0.83	0.98	25	empty
3	324	0.71	0.84	41	empty
4	342	0.71	0.83	41	empty
5	693	0.68	0.76	70	empty

Interfaces

3 interfaces between chains.

C–D · 1375 Å² buried · 27 hydrogen bonds · protein-protein
A–B · 1349 Å² buried · 28 hydrogen bonds · protein-protein
A–D · 149 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

3ZLH · Structure of group A Streptococcal enolase · the same entry in another collection · chain D against D, TM-score 1.00
Q5XD01 · AlphaFold monomer V2.0 prediction for enolase (Q5XD01) · a predicted model of the same protein · chain C against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5XD01
Elsewhere: RCSB PDB 3ZLH · PDBe 3ZLH · UniProt Q5XD01

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