MolNFT v1 · #84389 · protein
The structure of the traf domain of human TRAF4
3ZJB · TNF receptor-associated factor 4: “The structure of the traf domain of human TRAF4”. X-ray diffraction, 1 ligand (CL), 6 pockets (best druggability 0.76). MolNFT v1 #84389 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 3ZJB
- Type
- protein
- Length
- 528 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TNF receptor-associated factor 4
- UniProt
- Q9BUZ4
- Ligands
- CL
- Pockets
- 6 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 22% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TNF receptor-associated factor 4 | protein | 172 | 23% helix, 32% strand | Q9BUZ4 |
| B | TNF receptor-associated factor 4 | protein | 184 | 21% helix, 30% strand | Q9BUZ4 |
| C | TNF receptor-associated factor 4 | protein | 172 | 22% helix, 32% strand | Q9BUZ4 |
Ligands and binding sites
- CL · Chloride ion · ion · 3 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1010 | 0.76 | 0.78 | 65 | CL |
| 2 | 279 | 0.63 | 0.80 | 29 | empty |
| 3 | 324 | 0.60 | 0.78 | 30 | empty |
| 4 | 132 | 0.40 | 0.74 | 24 | empty |
| 5 | 58 | 0.35 | 0.78 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 954 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 916 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 884 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BUZ4
- Elsewhere: RCSB PDB 3ZJB · PDBe 3ZJB · UniProt Q9BUZ4
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