MolNFT v1 · #84194 · RNA
Full-length hammerhead ribozyme with G12A substitution at the general base position
3ZD4 · Hammerhead ribozyme, enzyme strand: “Full-length hammerhead ribozyme with G12A substitution at the general base position”. X-ray diffraction, 2 pockets (best druggability 0.67). MolNFT v1 #84194 on GenesisL1: 3D structure, binding…
- PDB
- 3ZD4
- Type
- RNA
- Length
- 63 nucleotides
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hammerhead ribozyme, enzyme strand; Hammerhead ribozyme, substrate strand
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hammerhead ribozyme, enzyme strand | rna | 43 | — | — |
| B | Hammerhead ribozyme, substrate strand | rna | 20 | — | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 636 | 0.67 | 0.78 | 37 | empty |
| 2 | 71 | 0.30 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1236 Ų buried · 98 hydrogen bonds · nucleic-nucleic
Modifications
Observed in the structure: 2 modified (nucleotide modification).
Compared structures
- 3ZD4 · Full-Length Hammerhead Ribozyme with G12A substitution at the general base position · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3ZD4 · PDBe 3ZD4
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