MolNFT v1 · #84188 · protein

Structure of GAPDH from thermosynechococcus elongatus

3ZCX · Glyceraldehyde-3-phosphate dehydrogenase: “Structure of GAPDH from thermosynechococcus elongatus”. X-ray diffraction, 1 ligand (NAD), 3 pockets (best druggability 0.66). MolNFT v1 #84188 on GenesisL1: 3D structure, binding sites and…

PDB: 3ZCX
Type: protein
Length: 675 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glyceraldehyde-3-phosphate dehydrogenase
EC: 1.2.1.13
UniProt: Q8DIW5
Ligands: NAD
Pockets: 3 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.13)	protein	338	30% helix, 28% strand	Q8DIW5
B	Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.13)	protein	337	30% helix, 28% strand	Q8DIW5

Ligands and binding sites

NAD · Nicotinamide-adenine-dinucleotide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	405	0.66	0.79	46	NAD
2	392	0.65	0.79	52	NAD
3	346	0.55	0.75	32	empty

Interfaces

1 interface between chains.

A–B · 507 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3ZCX · Structure of GAPDH from Thermosynechococcus elongatus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8DIW5
Elsewhere: RCSB PDB 3ZCX · PDBe 3ZCX · UniProt Q8DIW5

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