MolNFT v1 · #84163 · protein

X-ray structure of C-met kinase in complex with inhibitor (S)-6-(1-(6- (1-methyl-1H-pyrazol-4-yl)-(1,2,4)TRIAZOLO(4,3-B)PYRIDAZIN-3-yl) ethyl) quinoline.

3ZC5 · Hepatocyte growth factor receptor: “X-ray structure of C-met kinase in complex with inhibitor (S)-6-(1-(6…”. X-ray diffraction, 1 ligand (W9Z), 2 pockets (best druggability 0.66). MolNFT v1 #84163 on GenesisL1: 3D structure, binding…

PDB: 3ZC5
Type: protein
Length: 289 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hepatocyte growth factor receptor
EC: 2.7.10.1
UniProt: P08581
Ligands: W9Z
Pockets: 2 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hepatocyte growth factor receptor (EC 2.7.10.1)	protein	289	42% helix, 15% strand	P08581

Ligands and binding sites

W9Z · 6-{(1S)-1-[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]ethyl}quinoline · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	183	0.66	0.85	25	W9Z
2	179	0.51	0.77	26	empty

Compared structures

3ZC5 · X-ray Structure of c-Met kinase in complex with inhibitor (S)-6-(1-(6… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08581
Elsewhere: RCSB PDB 3ZC5 · PDBe 3ZC5 · UniProt P08581

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