MolNFT v1 · #83997 · protein
Crystal structure of TRX3 domain of uggt (detergent-unbound form)
3WZT · Udp-glucose-glycoprotein glucosyltransferase-like protein: “Crystal structure of TRX3 domain of uggt (detergent-unbound form)”. X-ray diffraction, 9 pockets (best druggability 0.78). MolNFT v1 #83997 on GenesisL1: 3D structure…
- PDB
- 3WZT
- Type
- protein
- Length
- 812 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Udp-glucose-glycoprotein glucosyltransferase-like protein
- UniProt
- G0SB58
- Pockets
- 9 · best druggability 0.78
Structure
x-ray diffraction · 6 distinct chains · 44% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Udp-glucose-glycoprotein glucosyltransferase-like protein | protein | 155 | 44% helix, 15% strand | G0SB58 |
| B | Udp-glucose-glycoprotein glucosyltransferase-like protein | protein | 156 | 44% helix, 15% strand | G0SB58 |
| C | Udp-glucose-glycoprotein glucosyltransferase-like protein | protein | 142 | 45% helix, 16% strand | G0SB58 |
| D | Udp-glucose-glycoprotein glucosyltransferase-like protein | protein | 154 | 42% helix, 15% strand | G0SB58 |
| E | Udp-glucose-glycoprotein glucosyltransferase-like protein | protein | 94 | 43% helix, 17% strand | G0SB58 |
| F | Udp-glucose-glycoprotein glucosyltransferase-like protein | protein | 111 | 45% helix, 19% strand | G0SB58 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 780 | 0.78 | 0.82 | 88 | empty |
| 2 | 456 | 0.58 | 0.74 | 63 | empty |
| 3 | 138 | 0.52 | 0.80 | 20 | empty |
| 4 | 99 | 0.44 | 0.78 | 18 | empty |
| 5 | 61 | 0.43 | 0.82 | 14 | empty |
Interfaces
8 interfaces between chains.
- A–B · 805 Ų buried · 7 hydrogen bonds · protein-protein
- D–E · 621 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 439 Ų buried · 0 hydrogen bonds · protein-protein
- B–D · 428 Ų buried · 0 hydrogen bonds · protein-protein
- E–F · 102 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 modified (engineered).
Compared structures
- 3WZT · Crystal structure of Trx3 domain of UGGT (detergent-unbound form) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G0SB58
- Elsewhere: RCSB PDB 3WZT · PDBe 3WZT · UniProt G0SB58
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