MolNFT v1 · #83954 · protein
C-terminal esterase domain of lc-EST1
3WYD · Lc-EST1C: “C-terminal esterase domain of lc-EST1”. X-ray diffraction, 4 pockets (best druggability 0.67). MolNFT v1 #83954 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3WYD
- Type
- protein
- Length
- 384 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lc-EST1C
- EC
- 3.1.1.1
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Lc-EST1C (EC 3.1.1.1) | protein | 193 | 40% helix, 23% strand | — |
| B | Lc-EST1C (EC 3.1.1.1) | protein | 191 | 41% helix, 23% strand | — |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 533 | 0.67 | 0.77 | 60 | empty |
| 2 | 134 | 0.48 | 0.78 | 25 | empty |
| 3 | 114 | 0.44 | 0.77 | 22 | empty |
| 4 | 53 | 0.33 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 539 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3WYD · C-terminal esterase domain of LC-Est1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3WYD · PDBe 3WYD
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