MolNFT v1 · #83779 · protein

Crystal structure analysis of cell division protein

3WT0 · Cell division protein ftsa: “Crystal structure analysis of cell division protein”. X-ray diffraction, 2 ligands (ATP, MG), 20 pockets (best druggability 0.73). MolNFT v1 #83779 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 3WT0
Type: protein
Length: 1,504 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division protein ftsa
UniProt: Q8NX33
Ligands: ATP, MG
Pockets: 20 · best druggability 0.73

Structure

x-ray diffraction · 3 distinct chains · 38% helix, 34% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Cell division protein ftsa	protein	376	38% helix, 34% strand	Q8NX33
C	Cell division protein ftsa	protein	374	38% helix, 34% strand	Q8NX33
D	Cell division protein ftsa	protein	378	38% helix, 34% strand	Q8NX33

Ligands and binding sites

ATP · Adenosine-5'-triphosphate · ligand · 4 copies · chains A, B, C, D
MG · Magnesium ion · metal · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	270	0.73	0.87	42	ATP, MG
2	241	0.72	0.88	39	ATP, MG
3	258	0.72	0.87	43	ATP, MG
4	336	0.71	0.84	44	ATP, MG
5	506	0.67	0.78	56	empty

Interfaces

3 interfaces between chains.

A–C · 558 Å² buried · 4 hydrogen bonds · protein-protein
B–D · 373 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 193 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

3WT0 · Crystal Structure Analysis of Cell Division Protein · the same entry in another collection · chain D against D, TM-score 1.00
Q8NX33 · AlphaFold monomer V2.0 prediction for cell division protein ftsa (Q8NX33) · a predicted model of the same protein · chain C against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NX33
Elsewhere: RCSB PDB 3WT0 · PDBe 3WT0 · UniProt Q8NX33

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.