MolNFT v1 · #83773 · protein

Crystal structure of beta-mannanase from streptomyces thermolilacinus

3WSU: “Crystal structure of beta-mannanase from streptomyces thermolilacinus”. X-ray diffraction, 1 ligand (NA), 4 pockets (best druggability 0.56). MolNFT v1 #83773 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3WSU
Type: protein
Length: 598 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Beta-mannanase
UniProt: F5HR99
Ligands: NA
Pockets: 4 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 36% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Beta-mannanase	protein	300	36% helix, 19% strand	F5HR99
B	Beta-mannanase	protein	298	35% helix, 19% strand	F5HR99

Ligands and binding sites

NA · Sodium ion · metal · 4 copies · chains A, B
GOL · Glycerol · additive · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.56	0.84	28	empty
2	320	0.56	0.75	32	NA, GOL
3	270	0.52	0.75	35	NA, GOL
4	73	0.36	0.77	24	empty

Interfaces

1 interface between chains.

A–B · 541 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

3WSU · Crystal structure of beta-mannanase from Streptomyces thermolilacinus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F5HR99
Elsewhere: RCSB PDB 3WSU · PDBe 3WSU · UniProt F5HR99

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