MolNFT v1 · #83656 · protein
Crystal structure of horse TLR9 (unliganded form)
3WPB · Toll-like receptor 9: “Crystal structure of horse TLR9 (unliganded form)”. X-ray diffraction, 2 ligands (NAG, SO4), 4 pockets (best druggability 0.54). MolNFT v1 #83656 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3WPB
- Type
- protein
- Length
- 752 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Toll-like receptor 9
- UniProt
- Q2EEY0
- Ligands
- NAG, SO4
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 10% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Toll-like receptor 9 | protein | 752 | 10% helix, 17% strand | Q2EEY0 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 182 | 0.54 | 0.79 | 32 | SO4 |
| 2 | 186 | 0.47 | 0.75 | 20 | empty |
| 3 | 52 | 0.27 | 0.74 | 16 | empty |
| 4 | 52 | 0.26 | 0.74 | 14 | empty |
Modifications
Observed in the structure: 8 disulfide, 3 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2EEY0
- Elsewhere: RCSB PDB 3WPB · PDBe 3WPB · UniProt Q2EEY0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.