MolNFT v1 · #8363 · protein
Phosphatidylinositol-specific phospholipase C in complex with glucosamine-(alpha-1-6)-myo-inositol
1GYM: “Phosphatidylinositol-specific phospholipase C in complex with glucosamine-(alpha-1-6)-myo-inositol”. X-ray diffraction, 1 ligand (MYG), 1 pocket (best druggability 0.47). MolNFT v1 #8363 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1GYM
- Type
- protein
- Length
- 296 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol-specific phospholipase C
- EC
- 3.1.4.10
- UniProt
- P14262
- Ligands
- MYG
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol-specific phospholipase C (EC 3.1.4.10) | protein | 296 | 34% helix, 21% strand | P14262 |
Ligands and binding sites
- MYG · (1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 149 | 0.47 | 0.78 | 28 | MYG |
Compared structures
- 1GYM · Phosphatidylinositol-specific phospholipase C in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
- P14262 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol phosphodiesterase (P14262) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14262
- Elsewhere: RCSB PDB 1GYM · PDBe 1GYM · UniProt P14262
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