MolNFT v1 · #83562 · protein

Crystal structure of an inward-facing eukaryotic ABC multitrug transporter G277V/A278V/A279V mutant

3WMF · ATP-binding cassette, sub-family B, member 1: “Crystal structure of an inward-facing eukaryotic ABC multitrug transporter G277V/A278V/A279V mutant”. X-ray diffraction, 7 pockets (best druggability 0.62). MolNFT v1 #83562 on…

PDB: 3WMF
Type: protein
Length: 588 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-binding cassette, sub-family B, member 1
UniProt: M1VAN7
Pockets: 7 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-binding cassette, sub-family B, member 1	protein	588	65% helix, 11% strand	M1VAN7

Ligands and binding sites

DMU · Decyl-beta-D-maltopyranoside · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	363	0.62	0.78	45	empty
2	126	0.54	0.82	28	empty
3	178	0.49	0.77	31	empty
4	191	0.47	0.75	20	empty
5	61	0.45	0.82	12	empty

Compared structures

3WMF · Crystal structure of an inward-facing eukaryotic ABC multitrug transporter… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt M1VAN7
Elsewhere: RCSB PDB 3WMF · PDBe 3WMF · UniProt M1VAN7

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