MolNFT v1 · #83444 · protein
Crystal structure of the Fab fragment of B2212A, a murine monoclonal antibody specific for the third fibronectin domain (FN3) of human ROBO1.
3WII · Anti-human ROBO1 antibody B2212A Fab light chain: “Crystal structure of the Fab fragment of B2212A, a murine monoclonal antibody specific for the third…”. X-ray diffraction, 11 pockets (best druggability 0.62). MolNFT v1 #83444 on…
- PDB
- 3WII
- Type
- protein
- Length
- 866 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-human ROBO1 antibody B2212A Fab light chain; Anti-human ROBO1 antibody B2212A Fab…
- Pockets
- 11 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L, M | Anti-human ROBO1 antibody B2212A Fab light chain | protein | 213 | 6% helix, 50% strand | — |
| H, I | Anti-human ROBO1 antibody B2212A Fab heavy chain | protein | 220 | 8% helix, 51% strand | — |
Pockets
11 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 421 | 0.62 | 0.77 | 40 | empty |
| 2 | 228 | 0.48 | 0.74 | 37 | empty |
| 3 | 120 | 0.44 | 0.77 | 24 | empty |
| 4 | 113 | 0.42 | 0.76 | 24 | empty |
| 5 | 113 | 0.40 | 0.75 | 25 | empty |
Interfaces
5 interfaces between chains.
- L–H · 1900 Ų buried · 15 hydrogen bonds · protein-protein
- M–I · 1862 Ų buried · 12 hydrogen bonds · protein-protein
- H–I · 301 Ų buried · 6 hydrogen bonds · protein-protein
- H–M · 61 Ų buried · 1 hydrogen bond · protein-protein
- L–I · 57 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 3WII · Crystal structure of the Fab fragment of B2212A, a murine monoclonal antibody specific… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3WII · PDBe 3WII
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