MolNFT v1 · #83388 · protein

Crystal structure of Q154L/T173I/R199M/P248S/H249/N276S mutant of meso-dapdh from clostridium tetani E88

3WGO · Meso-diaminopimelate dehydrogenase: “Crystal structure of Q154L/T173I/R199M/P248S/H249/N276S mutant of meso-dapdh from clostridium tetani E88”. X-ray diffraction, 5 pockets (best druggability 0.66). MolNFT v1 #83388 on GenesisL1: 3D…

PDB: 3WGO
Type: protein
Length: 647 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Meso-diaminopimelate dehydrogenase
EC: 1.4.1.16
UniProt: Q890V3
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Meso-diaminopimelate dehydrogenase (EC 1.4.1.16)	protein	323	40% helix, 26% strand	Q890V3
B	Meso-diaminopimelate dehydrogenase (EC 1.4.1.16)	protein	324	39% helix, 26% strand	Q890V3

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	516	0.66	0.77	51	empty
2	446	0.65	0.78	63	empty
3	186	0.45	0.74	37	empty
4	181	0.44	0.74	40	empty
5	52	0.28	0.75	14	empty

Interfaces

1 interface between chains.

A–B · 3035 Å² buried · 45 hydrogen bonds · protein-protein

Compared structures

3WGO · Crystal structure of Q154L/T173I/R199M/P248S/H249/N276S mutant of meso-dapdh from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q890V3
Elsewhere: RCSB PDB 3WGO · PDBe 3WGO · UniProt Q890V3

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