MolNFT v1 · #83315 · protein

Crystal structure of a niemann-pick type C2 protein from japanese carpenter ant

3WEA: “Crystal structure of a niemann-pick type C2 protein from japanese carpenter ant”. X-ray diffraction, 2 pockets (best druggability 0.76). MolNFT v1 #83315 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3WEA
Type: protein
Length: 264 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Niemann-pick type C2 protein
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Niemann-pick type C2 protein	protein	132	2% helix, 50% strand	—

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	403	0.76	0.85	39	empty
2	379	0.76	0.85	50	empty

Interfaces

1 interface between chains.

A–B · 429 Å² buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

3WEA · Crystal structure of a Niemann-Pick type C2 protein from Japanese carpenter ant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3WEA · PDBe 3WEA

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