MolNFT v1 · #83127 · protein
Crystal structure of CCM3 in complex with the C-terminal regulatory domain of MST4
3W8I · Programmed cell death protein 10: “Crystal structure of CCM3 in complex with the C-terminal regulatory domain of MST4”. X-ray diffraction, 1 pocket (best druggability 0.39). MolNFT v1 #83127 on GenesisL1: 3D structure, binding sites…
- PDB
- 3W8I
- Type
- protein
- Length
- 251 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Programmed cell death protein 10; SERINE/THREONINE-protein kinase MST4
- EC
- 2.7.11.1
- UniProt
- Q9BUL8, Q9P289
- Pockets
- 1 · best druggability 0.39
Structure
x-ray diffraction · 2 distinct chains · 80% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Programmed cell death protein 10 | protein | 184 | 79% helix, 0% strand | Q9BUL8 |
| B | SERINE/THREONINE-protein kinase MST4 (EC 2.7.11.1) | protein | 67 | 82% helix, 0% strand | Q9P289 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 108 | 0.39 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 1546 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 3W8I · Crystal structure of CCM3 in complex with the C-terminal regulatory domain of MST4 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9BUL8 · AlphaFold monomer V2.0 prediction for programmed cell death protein 10 (Q9BUL8) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q9P289 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase 26 (Q9P289) · a predicted model of the same protein · chain B against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BUL8
- Every structure of UniProt Q9P289
- Elsewhere: RCSB PDB 3W8I · PDBe 3W8I · UniProt Q9BUL8 · UniProt Q9P289
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