MolNFT v1 · #83088 · protein
Crystal structure of formyltetrahydrofolate deformylase from thermus thermophilus HB8
3W7B: “Crystal structure of formyltetrahydrofolate deformylase from thermus thermophilus HB8”. X-ray diffraction, 4 pockets (best druggability 0.53). MolNFT v1 #83088 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3W7B
- Type
- protein
- Length
- 570 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Formyltetrahydrofolate deformylase
- EC
- 3.5.1.10
- UniProt
- Q5SIP8
- Pockets
- 4 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 34% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Formyltetrahydrofolate deformylase (EC 3.5.1.10) | protein | 285 | 34% helix, 30% strand | Q5SIP8 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 310 | 0.53 | 0.74 | 43 | empty |
| 2 | 191 | 0.50 | 0.77 | 19 | empty |
| 3 | 234 | 0.49 | 0.74 | 32 | empty |
| 4 | 133 | 0.45 | 0.77 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1566 Ų buried · 38 hydrogen bonds · protein-protein
Compared structures
- 3W7B · Crystal structure of formyltetrahydrofolate deformylase from Thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SIP8
- Elsewhere: RCSB PDB 3W7B · PDBe 3W7B · UniProt Q5SIP8
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