MolNFT v1 · #83068 · protein

Crystal structure of melb apo-protyrosinase from asperugillus oryzae

3W6Q: “Crystal structure of melb apo-protyrosinase from asperugillus oryzae”. X-ray diffraction, 20 pockets (best druggability 0.77). MolNFT v1 #83068 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3W6Q
Type: protein
Length: 2,247 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tyrosinase
Pockets: 20 · best druggability 0.77

Structure

x-ray diffraction · 4 distinct chains · 36% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tyrosinase	protein	564	36% helix, 16% strand	—
B	Tyrosinase	protein	560	36% helix, 17% strand	—
C	Tyrosinase	protein	560	36% helix, 16% strand	—
D	Tyrosinase	protein	563	37% helix, 17% strand	—

Pockets

20 pockets found on a 1 Å grid, 19 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	989	0.77	0.79	92	empty
2	135	0.77	0.95	31	empty
3	128	0.75	0.94	29	empty
4	92	0.73	0.96	25	empty
5	107	0.72	0.94	25	empty

Interfaces

3 interfaces between chains.

C–D · 1913 Å² buried · 21 hydrogen bonds · protein-protein
A–B · 1907 Å² buried · 16 hydrogen bonds · protein-protein
B–C · 812 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

3W6Q · Crystal structure of melB apo-protyrosinase from Asperugillus oryzae · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 3W6Q · PDBe 3W6Q

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