MolNFT v1 · #82989 · protein
Crystal structure of KAP121P bound to NUP53P
3W3Y · Importin subunit beta-3: “Crystal structure of KAP121P bound to NUP53P”. X-ray diffraction, 5 pockets (best druggability 0.58). MolNFT v1 #82989 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3W3Y
- Type
- protein
- Length
- 1,034 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit beta-3; Nucleoporin NUP53
- UniProt
- P32337, Q03790
- Pockets
- 5 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit beta-3 | protein | 1026 | 77% helix, 1% strand | P32337 |
| B | Nucleoporin NUP53 | protein | 8 | 0% helix, 0% strand | Q03790 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 233 | 0.58 | 0.79 | 43 | empty |
| 2 | 62 | 0.50 | 0.85 | 15 | empty |
| 3 | 127 | 0.41 | 0.75 | 20 | empty |
| 4 | 80 | 0.38 | 0.77 | 14 | empty |
| 5 | 56 | 0.28 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 609 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 3W3Y · Crystal structure of Kap121p bound to Nup53p · the same entry in another collection · chain A against A, TM-score 1.00
- P32337 · AlphaFold monomer V2.0 prediction for importin subunit beta-3 (P32337) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q03790 · AlphaFold monomer V2.0 prediction for nucleoporin NUP53 (Q03790) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32337
- Every structure of UniProt Q03790
- Elsewhere: RCSB PDB 3W3Y · PDBe 3W3Y · UniProt P32337 · UniProt Q03790
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