MolNFT v1 · #82828 · protein

Structural insights into substrate and cofactor selection by SP2771

3VZ2 · Succinate-semialdehyde dehydrogenase: “Structural insights into substrate and cofactor selection by SP2771”. X-ray diffraction, 9 pockets (best druggability 0.85). MolNFT v1 #82828 on GenesisL1: 3D structure, binding sites and…

PDB: 3VZ2
Type: protein
Length: 914 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Succinate-semialdehyde dehydrogenase
UniProt: B1XMM6
Pockets: 9 · best druggability 0.85

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Succinate-semialdehyde dehydrogenase	protein	453	44% helix, 19% strand	B1XMM6
B	Succinate-semialdehyde dehydrogenase	protein	461	44% helix, 20% strand	B1XMM6

Pockets

9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1139	0.85	0.86	115	empty
2	284	0.63	0.80	36	empty
3	311	0.61	0.78	36	empty
4	323	0.57	0.76	46	empty
5	258	0.55	0.77	38	empty

Interfaces

1 interface between chains.

A–B · 2469 Å² buried · 41 hydrogen bonds · protein-protein

Compared structures

3VZ2 · Structural insights into substrate and cofactor selection by sp2771 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B1XMM6
Elsewhere: RCSB PDB 3VZ2 · PDBe 3VZ2 · UniProt B1XMM6

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