MolNFT v1 · #82784 · protein
HLA-A24 in complex with HIV-1 NEF134-10(WT)
3VXN · HLA class I histocompatibility antigen, a-24 alpha chain: “HLA-A24 in complex with HIV-1 NEF134-10(WT)”. X-ray diffraction, 4 pockets (best druggability 0.69). MolNFT v1 #82784 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 3VXN
- Type
- protein
- Length
- 383 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, a-24 alpha chain; Beta-2-microglobulin; 10-mer…
- UniProt
- P05534, P61769, Q9YYU8
- Pockets
- 4 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, a-24 alpha chain | protein | 274 | 26% helix, 40% strand | P05534 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| C | 10-mer peptide from protein nef | protein | 10 | 0% helix, 0% strand | Q9YYU8 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 633 | 0.69 | 0.78 | 60 | empty |
| 2 | 135 | 0.47 | 0.78 | 25 | empty |
| 3 | 88 | 0.42 | 0.78 | 17 | empty |
| 4 | 65 | 0.29 | 0.74 | 16 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1288 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 938 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05534
- Every structure of UniProt P61769
- Every structure of UniProt Q9YYU8
- Elsewhere: RCSB PDB 3VXN · PDBe 3VXN · UniProt P05534 · UniProt P61769 · UniProt Q9YYU8
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