MolNFT v1 · #82551 · protein
Small heat shock protein HSP14.0 of C-terminal deletion variant with C-terminal peptide
3VQM · Small heat shock protein STHSP14.0: “Small heat shock protein HSP14.0 of C-terminal deletion variant with C-terminal peptide”. X-ray diffraction, 20 pockets (best druggability 0.76). MolNFT v1 #82551 on GenesisL1: 3D structure…
- PDB
- 3VQM
- Type
- protein
- Length
- 1,528 residues
- Chains
- 23
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small heat shock protein STHSP14.0; C-terminal peptide from small heat shock protein…
- UniProt
- Q970D9
- Pockets
- 20 · best druggability 0.76
Structure
x-ray diffraction · 12 distinct chains · 7% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Small heat shock protein STHSP14.0 | protein | 111 | 9% helix, 45% strand | Q970D9 |
| B, I | Small heat shock protein STHSP14.0 | protein | 105 | 8% helix, 48% strand | Q970D9 |
| C | Small heat shock protein STHSP14.0 | protein | 103 | 4% helix, 47% strand | Q970D9 |
| D | Small heat shock protein STHSP14.0 | protein | 110 | 7% helix, 46% strand | Q970D9 |
| E | Small heat shock protein STHSP14.0 | protein | 109 | 9% helix, 45% strand | Q970D9 |
| F | Small heat shock protein STHSP14.0 | protein | 101 | 6% helix, 47% strand | Q970D9 |
| G, J | Small heat shock protein STHSP14.0 | protein | 112 | 13% helix, 45% strand | Q970D9 |
| H | Small heat shock protein STHSP14.0 | protein | 102 | 7% helix, 47% strand | Q970D9 |
| K, M | Small heat shock protein STHSP14.0 | protein | 108 | 6% helix, 43% strand | Q970D9 |
| L | Small heat shock protein STHSP14.0 | protein | 98 | 5% helix, 40% strand | Q970D9 |
| N | Small heat shock protein STHSP14.0 | protein | 99 | 8% helix, 44% strand | Q970D9 |
| O, P, Q, R, S, T, U, V, W | C-terminal peptide from small heat shock protein STHSP14.0 | protein | 5 | 0% helix, 20% strand | Q970D9 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 477 | 0.76 | 0.84 | 65 | empty |
| 2 | 269 | 0.75 | 0.88 | 49 | empty |
| 3 | 190 | 0.75 | 0.91 | 30 | empty |
| 4 | 714 | 0.71 | 0.78 | 66 | empty |
| 5 | 73 | 0.65 | 0.92 | 18 | empty |
Interfaces
40 interfaces between chains.
- A–B · 1968 Ų buried · 52 hydrogen bonds · protein-protein
- I–J · 1880 Ų buried · 51 hydrogen bonds · protein-protein
- E–F · 1794 Ų buried · 52 hydrogen bonds · protein-protein
- M–N · 1745 Ų buried · 39 hydrogen bonds · protein-protein
- G–H · 1739 Ų buried · 44 hydrogen bonds · protein-protein
Compared structures
- 3VQM · Small heat shock protein hsp14.0 of C-terminal deletion variant with C-terminal peptide · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q970D9
- Elsewhere: RCSB PDB 3VQM · PDBe 3VQM · UniProt Q970D9
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