MolNFT v1 · #82549 · protein

Small heat shock protein HSP14.0 of wild type

3VQK · Small heat shock protein STHSP14.0: “Small heat shock protein HSP14.0 of wild type”. X-ray diffraction, 6 pockets (best druggability 0.89). MolNFT v1 #82549 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3VQK
Type: protein
Length: 642 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Small heat shock protein STHSP14.0
UniProt: Q970D9
Pockets: 6 · best druggability 0.89

Structure

x-ray diffraction · 1 distinct chain · 4% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F	Small heat shock protein STHSP14.0	protein	107	4% helix, 7% strand	Q970D9

Pockets

6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1102	0.89	0.90	116	empty
2	728	0.86	0.89	76	empty
3	935	0.85	0.86	100	empty
4	728	0.84	0.87	73	empty
5	700	0.84	0.87	70	empty

Interfaces

7 interfaces between chains.

B–D · 1419 Å² buried · 24 hydrogen bonds · protein-protein
E–F · 1417 Å² buried · 27 hydrogen bonds · protein-protein
A–C · 1412 Å² buried · 26 hydrogen bonds · protein-protein
B–E · 642 Å² buried · 4 hydrogen bonds · protein-protein
A–B · 632 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

3VQK · Small heat shock protein hsp14.0 of wild type · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q970D9
Elsewhere: RCSB PDB 3VQK · PDBe 3VQK · UniProt Q970D9

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