MolNFT v1 · #82502 · protein
Crystal structure of human glutaminase in complex with inhibitor 4
3VP4 · Glutaminase kidney isoform, mitochondrial: “Crystal structure of human glutaminase in complex with inhibitor 4”. X-ray diffraction, 1 ligand (BP9), 1 pocket (best druggability 0.63). MolNFT v1 #82502 on GenesisL1: 3D structure…
- PDB
- 3VP4
- Type
- protein
- Length
- 312 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaminase kidney isoform, mitochondrial
- EC
- 3.5.1.2
- UniProt
- O94925
- Ligands
- BP9
- Pockets
- 1 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutaminase kidney isoform, mitochondrial (EC 3.5.1.2) | protein | 312 | 47% helix, 13% strand | O94925 |
Ligands and binding sites
- BP9 · 5,5'-butane-1,4-diylbis(1,3,4-thiadiazol-2-amine) · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 351 | 0.63 | 0.79 | 41 | empty |
Compared structures
- 3VP4 · Crystal structure of human glutaminase in complex with inhibitor 4 · the same entry in another collection · chain A against A, TM-score 1.00
- O94925 · AlphaFold monomer V2.0 prediction for glutaminase kidney isoform, mitochondrial (O94925) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O94925
- Elsewhere: RCSB PDB 3VP4 · PDBe 3VP4 · UniProt O94925
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.