MolNFT v1 · #82495 · protein

X-ray crystal structure of wild type hrtr in the apo form

3VOX · Transcriptional regulator: “X-ray crystal structure of wild type hrtr in the apo form”. X-ray diffraction, 4 pockets (best druggability 0.80). MolNFT v1 #82495 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3VOX
Type: protein
Length: 710 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional regulator
UniProt: Q9CHR1
Pockets: 4 · best druggability 0.80

Structure

x-ray diffraction · 3 distinct chains · 71% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional regulator	protein	181	69% helix, 0% strand	Q9CHR1
B, D	Transcriptional regulator	protein	177	71% helix, 0% strand	Q9CHR1
C	Transcriptional regulator	protein	175	72% helix, 0% strand	Q9CHR1

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1035	0.80	0.81	69	empty
2	959	0.78	0.80	67	empty
3	1024	0.76	0.79	77	empty
4	54	0.25	0.73	17	empty

Interfaces

3 interfaces between chains.

C–D · 1604 Å² buried · 17 hydrogen bonds · protein-protein
A–B · 1540 Å² buried · 17 hydrogen bonds · protein-protein
B–C · 573 Å² buried · 9 hydrogen bonds · protein-protein

Compared structures

3VOX · X-ray Crystal Structure of Wild Type HrtR in the Apo Form · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9CHR1
Elsewhere: RCSB PDB 3VOX · PDBe 3VOX · UniProt Q9CHR1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.