1510-N membrane-bound stomatin-specific protease K138A mutant in complex with a substrate peptide

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 25% strand (DSSP).

Ligands and binding sites

• CL · Chloride ion · ion · chains A
• IMD · Imidazole · additive · 3 copies · chains A, B
• GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

3 interfaces between chains.

• A–B · 1046 Ų buried · 18 hydrogen bonds · protein-protein
• B–C · 569 Ų buried · 7 hydrogen bonds · protein-protein
• A–C · 554 Ų buried · 11 hydrogen bonds · protein-protein

Compared structures

• 3VIV · 1510-N membrane-bound stomatin-specific protease K138A mutant in complex with a substrate… · the same entry in another collection · chain A against A, TM-score 1.00
• O59179 · AlphaFold monomer V2.0 prediction for membrane-bound protease PH1510 (O59179) · a predicted model of the same protein · chain A against A, TM-score 0.97
• O59180 · AlphaFold monomer V2.0 prediction for stomatin homolog PH1511 (O59180) · a predicted model of the same protein · chain C against A, TM-score 0.37

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O59179
• Every structure of UniProt O59180
• Elsewhere: RCSB PDB 3VIV · PDBe 3VIV · UniProt O59179 · UniProt O59180