MolNFT v1 · #82260 · protein
Crystal structure of the chicken cenp-T histone FOLD/CENP-W/CENP- S/CENP-X heterotetrameric complex, crystal form I
3VH5 · Cenp-S: “Crystal structure of the chicken cenp-T histone FOLD/CENP-W/CENP- S/CENP-X heterotetrameric complex, crystal…”. X-ray diffraction, 2 pockets (best druggability 0.50). MolNFT v1 #82260 on GenesisL1: 3D structure, binding…
- PDB
- 3VH5
- Type
- protein
- Length
- 344 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cenp-S; Cenp-X; Cenp-T; Cenp-W
- UniProt
- F1NPG5
- Pockets
- 2 · best druggability 0.50
Structure
x-ray diffraction · 4 distinct chains · 73% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cenp-S | protein | 100 | 82% helix, 4% strand | — |
| D | Cenp-X | protein | 75 | 71% helix, 5% strand | — |
| T | Cenp-T | protein | 94 | 69% helix, 4% strand | F1NPG5 |
| W | Cenp-W | protein | 75 | 69% helix, 3% strand | — |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 228 | 0.50 | 0.76 | 24 | empty |
| 2 | 99 | 0.41 | 0.77 | 16 | empty |
Interfaces
6 interfaces between chains.
- T–W · 2631 Ų buried · 23 hydrogen bonds · protein-protein
- A–D · 2563 Ų buried · 26 hydrogen bonds · protein-protein
- A–T · 610 Ų buried · 12 hydrogen bonds · protein-protein
- A–W · 236 Ų buried · 5 hydrogen bonds · protein-protein
- D–W · 129 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3VH5 · Crystal structure of the chicken CENP-T histone fold/CENP-W/CENP-S/CENP-X… · the same entry in another collection · chain A against A, TM-score 1.00
- F1NPG5 · AlphaFold monomer V2.0 prediction for centromere protein T (F1NPG5) · a predicted model of the same protein · chain T against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F1NPG5
- Elsewhere: RCSB PDB 3VH5 · PDBe 3VH5 · UniProt F1NPG5
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