MolNFT v1 · #82086 · protein
Crystal structure of formaldehyde treated empty human enterovirus 71 particle (room temperature)
3VBR · Genome polyprotein, capsid protein VP1: “Crystal structure of formaldehyde treated empty human enterovirus 71 particle (room temperature)”. X-ray diffraction, 9 pockets (best druggability 0.67). MolNFT v1 #82086 on GenesisL1: 3D…
- PDB
- 3VBR
- Type
- protein
- Length
- 694 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Genome polyprotein, capsid protein VP1; Genome polyprotein, capsid protein VP0; Genome…
- UniProt
- B2ZUN0
- Pockets
- 9 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 10% helix, 35% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Genome polyprotein, capsid protein VP1 | protein | 218 | 8% helix, 33% strand | B2ZUN0 |
| B | Genome polyprotein, capsid protein VP0 | protein | 237 | 10% helix, 38% strand | B2ZUN0 |
| C | Genome polyprotein, capsid protein VP3 | protein | 239 | 11% helix, 34% strand | B2ZUN0 |
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 348 | 0.67 | 0.81 | 29 | empty |
| 2 | 267 | 0.55 | 0.77 | 36 | empty |
| 3 | 125 | 0.48 | 0.79 | 27 | empty |
| 4 | 111 | 0.42 | 0.77 | 25 | empty |
| 5 | 80 | 0.41 | 0.79 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–C · 3074 Ų buried · 52 hydrogen bonds · protein-protein
- A–B · 1831 Ų buried · 31 hydrogen bonds · protein-protein
- B–C · 1550 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 3VBR · Crystal structure of formaldehyde treated empty human Enterovirus 71 particle (room… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B2ZUN0
- Elsewhere: RCSB PDB 3VBR · PDBe 3VBR · UniProt B2ZUN0
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