MolNFT v1 · #81993 · protein
S663A stable-5-lox
3V92 · Arachidonate 5-lipoxygenase: “S663A stable-5-lox”. X-ray diffraction, 1 ligand (FE2), 12 pockets (best druggability 0.83). MolNFT v1 #81993 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3V92
- Type
- protein
- Length
- 1,345 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Arachidonate 5-lipoxygenase
- EC
- 1.13.11.34
- UniProt
- P09917
- Ligands
- FE2
- Pockets
- 12 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Arachidonate 5-lipoxygenase (EC 1.13.11.34) | protein | 670 | 43% helix, 14% strand | P09917 |
| A | Arachidonate 5-lipoxygenase (EC 1.13.11.34) | protein | 675 | 43% helix, 14% strand | P09917 |
Ligands and binding sites
- FE2 · Fe (II) ion · metal · 2 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1189 | 0.83 | 0.84 | 124 | empty |
| 2 | 618 | 0.78 | 0.84 | 70 | empty |
| 3 | 90 | 0.77 | 0.98 | 26 | empty |
| 4 | 91 | 0.76 | 0.97 | 23 | empty |
| 5 | 441 | 0.75 | 0.84 | 67 | empty |
Interfaces
1 interface between chains.
- B–A · 964 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P09917
- Elsewhere: RCSB PDB 3V92 · PDBe 3V92 · UniProt P09917
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