MolNFT v1 · #81943 · protein

Crystal structure of the C-terminal domain of ebola virus VP30 (strain reston-89)

3V7O · Minor nucleoprotein VP30: “Crystal structure of the C-terminal domain of ebola virus VP30 (strain reston-89)”. X-ray diffraction, 3 pockets (best druggability 0.56). MolNFT v1 #81943 on GenesisL1: 3D structure, binding sites and…

PDB: 3V7O
Type: protein
Length: 329 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Minor nucleoprotein VP30
UniProt: Q8JPX6
Pockets: 3 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 59% helix, 9% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Minor nucleoprotein VP30	protein	126	72% helix, 0% strand	Q8JPX6
B	Minor nucleoprotein VP30	protein	203	51% helix, 14% strand	Q8JPX6

Ligands and binding sites

EDO · 1,2-ethanediol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	318	0.56	0.76	43	empty
2	50	0.32	0.77	10	empty
3	56	0.27	0.74	15	empty

Interfaces

1 interface between chains.

A–B · 2045 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

3V7O · Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8JPX6
Elsewhere: RCSB PDB 3V7O · PDBe 3V7O · UniProt Q8JPX6

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