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MolNFT v1 · #81920 · protein + RNA

Crystal structure of fbf-2 in complex with a mutant gld-1 FBEA13 RNA

3V6Y · Fem-3 mRNA-binding factor 2: “Crystal structure of fbf-2 in complex with a mutant gld-1 FBEA13 RNA”. X-ray diffraction, 2 pockets (best druggability 0.38). MolNFT v1 #81920 on GenesisL1: 3D structure, binding sites and pockets in…

PDB
3V6Y
Type
protein + RNA
Length
403 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Fem-3 mRNA-binding factor 2; RNA (5'-R(*UP*AP*CP*UP*GP*UP*GP*CP*CP*AP*UP*AP*C)-3')
UniProt
Q09312
Pockets
2 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 71% helix, 2% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
AFem-3 mRNA-binding factor 2protein39371% helix, 2% strandQ09312
BRNA (5'-R(*UP*AP*CP*UP*GP*UP*GP*CP*CP*AP*UP*AP*C)-3')rna10——

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
1610.380.7913empty
2620.300.7413empty

Interfaces

1 interface between chains.

  • A–B · 1469 Ų buried · 53 hydrogen bonds · protein-nucleic

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

  • 3V6Y · crystal structure of FBF-2 in complex with a mutant gld-1 FBEa13 RNA · the same entry in another collection · chain A against A, TM-score 1.00
  • Q09312 · AlphaFold monomer V2.0 prediction for fem-3 mRNA-binding factor 2 (Q09312) · a predicted model of the same protein · chain A against A, TM-score 0.99

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