MolNFT v1 · #81843 · protein
Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein auxiliary factor 2 (U2AF) from mus musculus at 1.80 a resolution
3V4M · Splicing factor U2AF 65 kda subunit: “Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein auxiliary factor 2 (U2AF)…”. X-ray diffraction, 2 ligands (NA, CL), 5 pockets (best druggability 0.49). MolNFT…
- PDB
- 3V4M
- Type
- protein
- Length
- 209 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Splicing factor U2AF 65 kda subunit
- UniProt
- P26369
- Ligands
- NA, CL
- Pockets
- 5 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Splicing factor U2AF 65 kda subunit | protein | 105 | 33% helix, 26% strand | P26369 |
| B | Splicing factor U2AF 65 kda subunit | protein | 104 | 34% helix, 22% strand | P26369 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.49 | 0.84 | 12 | empty |
| 2 | 120 | 0.40 | 0.75 | 24 | CL, NA |
| 3 | 68 | 0.35 | 0.76 | 15 | empty |
| 4 | 67 | 0.34 | 0.76 | 23 | empty |
| 5 | 60 | 0.28 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 442 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 3V4M · Crystal structure of a RNA binding domain of a U2 small nuclear ribonucleoprotein… · the same entry in another collection · chain A against A, TM-score 1.00
- P26369 · AlphaFold monomer V2.0 prediction for splicing factor U2AF 65 kda subunit (P26369) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26369
- Elsewhere: RCSB PDB 3V4M · PDBe 3V4M · UniProt P26369
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.