MolNFT v1 · #81794 · protein
Crystal structure of MCPIP1 conserved domain with zinc-finger motif
3V33 · Ribonuclease ZC3H12A: “Crystal structure of MCPIP1 conserved domain with zinc-finger motif”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #81794 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 3V33
- Type
- protein
- Length
- 323 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribonuclease ZC3H12A
- EC
- 3.1.-.-
- UniProt
- Q5D1E8
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ribonuclease ZC3H12A (EC 3.1.-.-) | protein | 163 | 37% helix, 24% strand | Q5D1E8 |
| B | Ribonuclease ZC3H12A (EC 3.1.-.-) | protein | 160 | 39% helix, 24% strand | Q5D1E8 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 328 | 0.62 | 0.79 | 45 | empty |
| 2 | 69 | 0.40 | 0.79 | 15 | empty |
| 3 | 82 | 0.30 | 0.72 | 14 | empty |
| 4 | 64 | 0.28 | 0.73 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 993 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3V33 · Crystal structure of MCPIP1 conserved domain with zinc-finger motif · the same entry in another collection · chain A against A, TM-score 1.00
- Q5D1E8 · AlphaFold monomer V2.0 prediction for endoribonuclease ZC3H12A (Q5D1E8) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5D1E8
- Elsewhere: RCSB PDB 3V33 · PDBe 3V33 · UniProt Q5D1E8
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