MolNFT v1 · #81651 · protein

Crystal structure of rat DNA polymerase beta mutator I260Q apoenzyme

3UXO: “Crystal structure of rat DNA polymerase beta mutator I260Q apoenzyme”. X-ray diffraction, 4 pockets (best druggability 0.68). MolNFT v1 #81651 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3UXO
Type: protein
Length: 650 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA polymerase beta
EC: 2.7.7.7, 4.2.99.-
UniProt: P06766
Pockets: 4 · best druggability 0.68

Structure

x-ray diffraction · 1 distinct chain · 50% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	DNA polymerase beta (EC 2.7.7.7, 4.2.99.-)	protein	325	50% helix, 13% strand	P06766

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	858	0.68	0.75	94	empty
2	56	0.63	0.93	18	empty
3	95	0.38	0.75	23	empty
4	128	0.37	0.73	29	empty

Interfaces

1 interface between chains.

A–B · 513 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

3UXO · Crystal Structure of Rat DNA Polymerase Beta Mutator I260Q Apoenzyme · the same entry in another collection · chain A against A, TM-score 1.00
P06766 · AlphaFold monomer V2.0 prediction for DNA polymerase beta (P06766) · a predicted model of the same protein · chain B against A, TM-score 0.73

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06766
Elsewhere: RCSB PDB 3UXO · PDBe 3UXO · UniProt P06766

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