MolNFT v1 · #81628 · protein

Crystal structure of uvra-uvrb complex

3UWX · Excinuclease ABC, a subunit: “Crystal structure of uvra-uvrb complex”. X-ray diffraction, 1 ligand (ZN), 18 pockets (best druggability 0.81). MolNFT v1 #81628 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3UWX
Type: protein
Length: 1,540 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Excinuclease ABC, a subunit; Uvrabc system protein B
UniProt: E8SW61, E8SW62
Ligands: ZN
Pockets: 18 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Excinuclease ABC, a subunit	protein	945	36% helix, 19% strand	E8SW61
B	Uvrabc system protein B	protein	595	43% helix, 18% strand	E8SW62

Ligands and binding sites

ZN · Zinc ion · metal · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1064	0.81	0.82	114	empty
2	637	0.77	0.82	56	empty
3	764	0.73	0.78	73	empty
4	160	0.71	0.90	29	empty
5	101	0.67	0.91	26	empty

Interfaces

1 interface between chains.

A–B · 868 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

3UWX · Crystal structure of UvrA-UvrB complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E8SW61
Every structure of UniProt E8SW62
Elsewhere: RCSB PDB 3UWX · PDBe 3UWX · UniProt E8SW61 · UniProt E8SW62

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