MolNFT v1 · #81558 · protein
Crystal structure of mono- and diacylglycerol lipase from malassezia globosa
3UUE · LIP1, secretory lipase (family 3): “Crystal structure of mono- and diacylglycerol lipase from malassezia globosa”. X-ray diffraction, 4 ligands (MAN, NAG, BMA), 1 pocket (best druggability 0.40). MolNFT v1 #81558 on GenesisL1: 3D…
- PDB
- 3UUE
- Type
- protein
- Length
- 279 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- LIP1, secretory lipase (family 3)
- UniProt
- A8PUY1
- Ligands
- MAN, NAG, BMA, CL
- Pockets
- 1 · best druggability 0.40
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | LIP1, secretory lipase (family 3) | protein | 279 | 32% helix, 21% strand | A8PUY1 |
Ligands and binding sites
- MAN · alpha-D-mannopyranose · sugar · 3 copies · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- BMA · beta-D-mannopyranose · sugar
- CL · Chloride ion · ion · chains A
- GOL · Glycerol · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 51 | 0.40 | 0.82 | 14 | empty |
Modifications
Observed in the structure: 2 glycan, 1 disulfide (disulfide, N-glycosylation, O-glycosylation).
Compared structures
- 3UUE · Crystal structure of mono- and diacylglycerol lipase from Malassezia globosa · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A8PUY1
- Elsewhere: RCSB PDB 3UUE · PDBe 3UUE · UniProt A8PUY1
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