MolNFT v1 · #81546 · protein

Salmonella typhi OSMOPORIN(OMPC):AN outer membrane protein

3UU2 · Outer membrane protein C: “Salmonella typhi OSMOPORIN(OMPC):AN outer membrane protein”. X-ray diffraction, 10 pockets (best druggability 0.82). MolNFT v1 #81546 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 3UU2
Type: protein
Length: 894 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Outer membrane protein C
UniProt: P0A263
Pockets: 10 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 56% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Outer membrane protein C	protein	298	5% helix, 56% strand	P0A263

Pockets

10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	155	0.82	0.96	29	empty
2	1063	0.70	0.75	108	empty
3	940	0.67	0.73	86	empty
4	641	0.63	0.74	48	empty
5	177	0.46	0.75	31	empty

Interfaces

3 interfaces between chains.

B–C · 1442 Å² buried · 25 hydrogen bonds · protein-protein
A–B · 1399 Å² buried · 18 hydrogen bonds · protein-protein
A–C · 1373 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

3UU2 · Salmonella typhi osmoporin(OmpC):an Outer Membrane Protein · the same entry in another collection · chain A against A, TM-score 1.00
P0A263 · AlphaFold monomer V2.0 prediction for outer membrane porin C (P0A263) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A263
Elsewhere: RCSB PDB 3UU2 · PDBe 3UU2 · UniProt P0A263

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