MolNFT v1 · #81506 · protein

Structure of the precursor of a thermostable variant of papain at 3.8 a resolution from a crystal soaked at pH 4

3USV: “Structure of the precursor of a thermostable variant of papain at 3.8 a resolution from a crystal soaked at…”. X-ray diffraction, 8 pockets (best druggability 0.81). MolNFT v1 #81506 on GenesisL1: 3D structure, binding sites and…

PDB: 3USV
Type: protein
Length: 616 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Papain
EC: 3.4.22.2
UniProt: P00784
Pockets: 8 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 16% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Papain (EC 3.4.22.2)	protein	308	16% helix, 4% strand	P00784

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	883	0.81	0.84	112	empty
2	885	0.80	0.82	106	empty
3	928	0.79	0.82	120	empty
4	284	0.60	0.79	44	empty
5	228	0.57	0.79	43	empty

Interfaces

1 interface between chains.

A–C · 16 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

3USV · Structure of the precursor of a thermostable variant of papain at 3.8 A resolution from a… · the same entry in another collection · chain A against A, TM-score 1.00
P00784 · AlphaFold monomer V2.0 prediction for papain (P00784) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00784
Elsewhere: RCSB PDB 3USV · PDBe 3USV · UniProt P00784

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