MolNFT v1 · #81392 · protein
A general strategy for the generation of human antibody variable domains with increased aggregation resistance
3UPA · Kappa light chain variable domain: “A general strategy for the generation of human antibody variable domains with increased aggregation resistance”. X-ray diffraction, 2 pockets (best druggability 0.33). MolNFT v1 #81392 on…
- PDB
- 3UPA
- Type
- protein
- Length
- 214 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kappa light chain variable domain
- Pockets
- 2 · best druggability 0.33
Structure
x-ray diffraction · 1 distinct chain · 3% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Kappa light chain variable domain | protein | 107 | 3% helix, 50% strand | — |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.33 | 0.74 | 20 | empty |
| 2 | 58 | 0.31 | 0.76 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 537 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3UPA · A general strategy for the generation of human antibody variable domains with increased… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 3UPA · PDBe 3UPA
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.