MolNFT v1 · #81353 · protein
JAC1 co-chaperone from saccharomyces cerevisiae, 5-182 clone
3UO3 · J-type co-chaperone JAC1, mitochondrial: “JAC1 co-chaperone from saccharomyces cerevisiae, 5-182 clone”. X-ray diffraction, 4 pockets (best druggability 0.77). MolNFT v1 #81353 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 3UO3
- Type
- protein
- Length
- 321 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- J-type co-chaperone JAC1, mitochondrial
- UniProt
- P53193
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | J-type co-chaperone JAC1, mitochondrial | protein | 174 | 66% helix, 0% strand | P53193 |
| B | J-type co-chaperone JAC1, mitochondrial | protein | 147 | 69% helix, 0% strand | P53193 |
Ligands and binding sites
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 733 | 0.77 | 0.82 | 74 | empty |
| 2 | 52 | 0.34 | 0.78 | 14 | empty |
| 3 | 59 | 0.30 | 0.74 | 10 | empty |
| 4 | 76 | 0.29 | 0.72 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 857 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 3UO3 · Jac1 co-chaperone from Saccharomyces cerevisiae, 5-182 clone · the same entry in another collection · chain A against A, TM-score 1.00
- P53193 · AlphaFold monomer V2.0 prediction for J-type co-chaperone JAC1, mitochondrial (P53193) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53193
- Elsewhere: RCSB PDB 3UO3 · PDBe 3UO3 · UniProt P53193
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