MolNFT v1 · #8132 · protein
Solution structure of groes-ADP7-groel-ATP7 complex by cryo-EM
1GRU: “Solution structure of groes-ADP7-groel-ATP7 complex by cryo-EM”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #8132 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1GRU
- Type
- protein
- Length
- 8,015 residues
- Chains
- 21
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Groel; Groes
- UniProt
- P06139, P05380
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 42% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L, M, N | Groel | protein | 524 | 50% helix, 15% strand | P06139 |
| O, P, Q, R, S, T, U | Groes | protein | 97 | 0% helix, 38% strand | P05380 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 376 | 0.81 | 0.90 | 57 | empty |
| 2 | 388 | 0.81 | 0.90 | 60 | empty |
| 3 | 781 | 0.81 | 0.84 | 88 | empty |
| 4 | 402 | 0.81 | 0.90 | 57 | empty |
| 5 | 398 | 0.81 | 0.89 | 59 | empty |
Interfaces
46 interfaces between chains.
- C–D · 1576 Ų buried · 20 hydrogen bonds · protein-protein
- A–G · 1569 Ų buried · 20 hydrogen bonds · protein-protein
- K–L · 1564 Ų buried · 25 hydrogen bonds · protein-protein
- B–C · 1555 Ų buried · 20 hydrogen bonds · protein-protein
- D–E · 1553 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1GRU · Solution structure of groes-ADP7-groel-ATP7 complex by cryo-EM · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06139
- Every structure of UniProt P05380
- Elsewhere: RCSB PDB 1GRU · PDBe 1GRU · UniProt P06139 · UniProt P05380
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.